Women will break the current record of 84 serving at the same time in the U.S. House.
With ballots still being counted across the country, women have won 75 seats and are assured of victory in 9 districts where women are the only major-party candidates.
From the Women's March opposing President Donald Trump the day after he was inaugurated in January 2017 through a stream of sexual assault accusations later that year that sparked the #MeToo movement, outrage and organizing by women have defined Democratic Party politics this election cycle.
More than 230 women, many of them first-time candidates, were on the general-election ballots in House races.
Despite the gains, men will continue to hold the vast majority of House seats.
Democrats have picked up at least 23 House seats, putting them on track to reach the 218 needed to seize control from Republicans after eight years.
Democrats knocked off at least 17 GOP incumbents, picking up moderate, suburban districts across the country. Democrats won seats stretching from suburban Washington, New York and Philadelphia to outside Miami, Chicago and Denver.
West Coast results were still coming.
Democrat Abigail Spanberger of Virginia defeated Republican incumbent Dave Brat in suburban Richmond to put Democrats over the top.
Nancy Pelosi is telling Democratic lawmakers and supporters that elections are about the future and "thank you all for making the future better for all of America's children."
Pelosi spoke as Democrats closed in on control of the House.
Pelosi said the election Tuesday was about more than Republicans and Democrats. It was about restoring the Constitution and providing a balance to the Trump administration.
She says the election is also about stopping what she described as the GOP's attacks on entitlement programs and the Affordable Care Act.
She says Democrats will find common ground when they can and stand their ground when necessary.